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The medical management consists of a combination of at least a drug for angina relief plus drugs to improve prognosis, as well as use of sublingual nitroglycerin for chest pain management.

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Overexpression of cardiac LPL in mice is associated with adaptations in the myocardium similar to diabetes, including increased fatty acid uptake and the development of cardiomyopathies ().

However, restenosis develops in only a minority of patients who receive bare-metal stents, and angina develops in only some of those patients (11% of the patients in our trial who were treated with PCI underwent a repeat procedure within 12 months).

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Patients on traditional AA medications were required to have concurrent sublingual nitroglycerin.

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For example, baseline angina-frequency scores on the Seattle Angina Questionnaire were 71 for both treatment groups when either the missing-at-random or the pattern-mixture model was used.

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ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC).

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Table 3 below summarizes the mean peak and trough plasma ranolazine concentrations, in terms of ranolazine dihydrochloride base, for all patients by gender and for each dosing regimen.

Similar incremental benefits from PCI were seen in some but not all RAND-36 domains.

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By ameliorating calcium overload, ranolazine may reduce RV diastolic tension and improve myocardial blood flow during diastole in the ischemic RV, thereby improving RV performance and contractility.

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The patients with most severe disease were selected for CABG rather than PCI and were a higher-risk group that drew a greater benefit from early revascularization (reduction of MI compared with OMT).

The frequency of premature permanent cessation of study drug in our trial is comparable with other contemporary trials of long-term therapy after presentation with ACS.

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